Development of siRNA-probes for studying intracellular trafficking of siRNA nanoparticles
نویسندگان
چکیده
منابع مشابه
Development of siRNA-probes for studying intracellular trafficking of siRNA nanoparticles.
One important barrier facing the delivery of short interfering RNAs (siRNAs) via synthetic nanoparticles is the rate of nanoparticle disassembly. However, our ability to optimize the release kinetics of siRNAs from nanoparticles for maximum efficacy is limited by the lack of methods to track their intracellular disassembly. Towards this end, we describe the design of two different siRNA-based f...
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ژورنال
عنوان ژورنال: Integrative Biology
سال: 2012
ISSN: 1757-9708
DOI: 10.1039/c2ib20155k